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| 论文编号: |
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| 第一作者所在部门: |
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| 中文论文题目: |
The implication of salience network abnormalities in young male adult smokers
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| 英文论文题目: |
The implication of salience network abnormalities in young male adult smokers
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| 论文题目英文: |
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| 作者: |
Li, Yangding
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| 论文出处: |
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| 刊物名称: |
BRAIN IMAGING AND BEHAVIOR
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| 年: |
2017
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| 卷: |
11 |
| 期: |
4 |
| 页: |
943-953 |
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| 收录类别: |
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| 影响因子: |
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| 摘要: |
Studying the neural correlates of smoking behaviors in young adulthood is of great importance to improve treatment outcomes. In previous addiction studies, the important roles of the salience network (SN) in drug cue processing and cognitive control have been revealed. Unfortunately, few studies focused on the resting-state functional connectivity and structural integrity abnormalities of SN in young adult smokers, and less is known about its association with smoking behaviors and cognitive control deficits. Thirty-one young male adult smokers and 30 age-, education- and gender-matched nonsmokers participated in this study. The structural and functional connectivity differences of SN were investigated between young adult smokers and nonsmokers by using diffusion tensor imaging (DTI) and resting-state functional connectivity (RSFC), which were then correlated with the smoking behavioral assessments (pack-years and Fagerstrom Test for Nicotine Dependence (FTND)) as well as impaired cognitive control measured by the Stroop task. Within SN, reduced RSFC and increased fractional anisotropy (FA) were found between the anterior cingulate cortex (ACC) and the right insula in young adult smokers relative to nonsmokers. The RSFC between the ACC and right insula was negatively correlated with the number of errors during the incongruent condition of the Stroop task in young adult smokers. Additionally, the right insula-ACC RSFC was negatively correlated with pack-years in young adult smokers. Our results revealed abnormal RSFC and structural integrity within the SN in young adult smokers, which shed new insights into the neural mechanism of nicotine dependence. |
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