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| 论文编号: |
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| 第一作者所在部门: |
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| 中文论文题目: |
The Left Dorsolateral Prefrontal Cortex and Caudate Pathway: New Evidence for Cue-Induced Craving of Smokers
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| 英文论文题目: |
The Left Dorsolateral Prefrontal Cortex and Caudate Pathway: New Evidence for Cue-Induced Craving of Smokers
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| 论文题目英文: |
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| 作者: |
Yuan, Kai
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| 论文出处: |
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| 刊物名称: |
HUMAN BRAIN MAPPING
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| 年: |
2017
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| 卷: |
38 |
| 期: |
9 |
| 页: |
4644-4656 |
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| 影响因子: |
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| 摘要: |
Although the activation of the prefrontal cortex (PFC) and the striatum had been found in smoking cue induced craving task, whether and how the functional interactions and white matter integrity between these brain regions contribute to craving processing during smoking cue exposure remains unknown. Twenty-five young male smokers and 26 age-and gender-matched nonsmokers participated in the smoking cue-reactivity task. Craving related brain activation was extracted and psychophysiological interactions (PPI) analysis was used to specify the PFC-efferent pathways contributed to smoking cue-induced craving. Diffusion tensor imaging (DTI) and probabilistic tractography was used to explore whether the fiber connectivity strength facilitated functional coupling of the circuit with the smoking cue-induced craving. The PPI analysis revealed the negative functional coupling of the left dorsolateral prefrontal cortex (DLPFC) and the caudate during smoking cue induced craving task, which positively correlated with the craving score. Neither significant activation nor functional connectivity in smoking cue exposure task was detected in nonsmokers. DTI analyses revealed that fiber tract integrity negatively correlated with functional coupling in the DLPFC-caudate pathway and activation of the caudate induced by smoking cue in smokers. Moreover, the relationship between the fiber connectivity integrity of the left DLPFC-caudate and smoking cue induced caudate activation can be fully mediated by functional coupling strength of this circuit in smokers. The present study highlighted the left DLPFC-caudate pathway in smoking cue-induced craving in smokers, which may reflect top-down prefrontal modulation of striatal reward processing in smoking cue induced craving processing. (C) 2017 Wiley Periodicals, Inc. |
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