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| 论文编号: |
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| 第一作者所在部门: |
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| 中文论文题目: |
A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer
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| 英文论文题目: |
A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer
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| 论文题目英文: |
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| 作者: |
Hu, Yanyan
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| 论文出处: |
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| 刊物名称: |
ADVANCED MATERIALS
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| 年: |
2017
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| 卷: |
29 |
| 期: |
33 |
| 页: |
1-9 |
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| 摘要: |
Although nanoparticle-based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine-125 (I-125) interstitial brachytherapy (IBT-125-I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti-urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT-125-I, a 25% higher median survival rate of IPTT with complete ablation by one-time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients. |
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