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| 论文编号: |
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| 第一作者所在部门: |
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| 中文论文题目: |
Altered resting state functional connectivity of anterior insula in young smokers
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| 英文论文题目: |
Altered resting state functional connectivity of anterior insula in young smokers
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| 论文题目英文: |
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| 作者: |
Bi, Yanzhi
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| 论文出处: |
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| 刊物名称: |
BRAIN IMAGING AND BEHAVIOR
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| 年: |
2017
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| 卷: |
11 |
| 期: |
1 |
| 页: |
155-165 |
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| 收录类别: |
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| 影响因子: |
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| 摘要: |
The insula has been implicated in cognitive control and craving, all of which are critical to the clinical manifestations of nicotine dependence. However, little evidence exists about the abnormalities in resting state functional connectivity (RSFC) of the insula in young smokers, which might improve our understanding of the neural mechanisms of nicotine dependence. Due to the structural and functional heterogeneity of the insula, the RSFC patterns of both left and right anterior (AI) and posterior insula (PI) were investigated in young smokers and non-smokers. Meanwhile, the relationship was assessed between the neuroimaging findings and clinical information (pack-years, FTND, and craving) as well as cognitive control deficits measured by Stroop task performance. Compared with non-smokers, young smokers showed reduced RSFC between right AI and anterior cingulate cortex (ACC), ventromedial prefrontal cortex (VMPFC), amygdala, left dorsolateral prefrontal cortex, and dorsal striatum. Additionally, left AI showed reduced RSFC with ACC. Both left and right PI network differences were not observed between two groups. Moreover, in young smokers, FTND and incongruent errors in the Stroop task were negatively correlated with the RSFC between AI and ACC. Craving scores showed a significantly negative relationship with the RSFC strength between right AI and left VMPFC. These results provide a more thorough network-level understanding the role of insula in cigarette smoking. The findings provide new insights into the roles of AI-ACC circuit in cognitive control deficits and right AI-VMPFC circuit relevant to the craving of nicotine dependence for young smokers. |
| 英文摘要: |
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