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| 论文编号: |
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| 第一作者所在部门: |
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| 中文论文题目: |
Neural correlates of 12-h abstinence-induced craving in young adult smokers: a resting-state study
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| 英文论文题目: |
Neural correlates of 12-h abstinence-induced craving in young adult smokers: a resting-state study
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| 论文题目英文: |
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| 作者: |
Li, Yangding
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| 论文出处: |
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| 刊物名称: |
BRAIN IMAGING AND BEHAVIOR
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| 年: |
2017
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| 卷: |
11 |
| 期: |
3 |
| 页: |
677-684 |
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| 摘要: |
Studying the neural correlates of craving to smoke in young adulthood is of great importance to improve treatment outcomes in nicotine dependence. Previous nicotine dependence studies mainly focused on the neural substrates of craving elicited by smoking-related cues. More explicit attention to abstinence-induced craving during resting state in nicotine dependence has the potential to yield valuable information about craving, and characterizing this kind of craving is critical for developing effective interventions. Twenty-five young male smokers were enrolled in the present study. A within-subject experiment design was carried out to compare regional homogeneity (ReHo) between 12-h smoking abstinence and smoking satiety conditions during resting state in young adult smokers. Then, the ReHo changes associated with smoking abstinence (compared with satiety) were further examined for correlations with abstinence-induced changes in subjective craving. We found young adult smokers in abstinence state (compared with satiety) had higher ReHo in brain regions in fronto-striatal circuits including bilateral caudate, anterior cingulate cortex (ACC) and bilateral dorsal lateral prefrontal cortex (DLPFC), as well as brain regions in default mode network (DMN) including posterior cingulate cortex (PCC)/precuneus and angular gyrus. Additionally, we found the ReHo changes of the ACC and the bilateral caudate were positively correlated with the changes in craving induced by abstinence (i.e., abstinence minus satiety) in young adult smokers. The present findings improve the understanding of the effects of acute smoking abstinence on spontaneous brain activity and may contribute new insights into the neural mechanism of abstinence-induced craving in nicotine dependence. |
| 英文摘要: |
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