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| 论文编号: |
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| 第一作者所在部门: |
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| 中文论文题目: |
Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery
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| 英文论文题目: |
Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery
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| 论文题目英文: |
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| 作者: |
Hu, Zhenhua
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| 论文出处: |
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| 刊物名称: |
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
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| 年: |
2017
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| 卷: |
13 |
| 期: |
4 |
| 页: |
1323-1331 |
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| 摘要: |
Fluorescent molecular imaging technique has been actively explored for optical image-guided cancer surgery in pre-clinical and clinical research and has attracted many attentions. However, the efficacy of the fluorescent image-guided cancer surgery can be compromised by the low signal-to-noise ratio caused by the external light excitation. This study presents a novel nanoparticle-mediated radiopharmaceutical-excited fluorescent (REF) image-guided cancer surgery strategy, which employs the internal dual-excitation of europium oxide nanoparticles through both gamma rays and Cerenkov luminescence emitted from radiopharmaceuticals. The performance of the novel image-guided surgery technique was systematically evaluated using subcutaneous breast cancer 4 T1 tumor models, orthotropic and orthotropic-ectopic hepatocellular carcinoma tumor-bearingmice. The results reveal that the novel REF image-guided cancer surgery technique exhibits high performance of detecting invisible ultra-small size tumor (even less than 1 mm) and residual tumor tissue. Our study demonstrates the high potential of the novel image-guided cancer surgery for precise tumor resection. (C) 2017 Elsevier Inc. All rights reserved. |
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