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| 论文编号: |
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| 第一作者所在部门: |
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| 中文论文题目: |
Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas
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| 英文论文题目: |
Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas
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| 论文题目英文: |
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| 作者: |
Bai, Yan
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| 论文出处: |
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| 刊物名称: |
ONCOTARGET
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| 年: |
2017
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| 卷: |
8 |
| 期: |
4 |
| 页: |
5834-5842 |
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| 影响因子: |
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| 摘要: |
Using noninvasive magnetic resonance imaging techniques to accurately evaluate the grading and cellularity of gliomas is beneficial for improving the patient outcomes. Amide proton transfer imaging is a noninvasive molecular magnetic resonance imaging technique based on chemical exchange saturation transfer mechanism that detects endogenous mobile proteins and peptides in biological tissues. Between August 2012 and November 2015, a total number of 44 patients with pathologically proven gliomas were included in this study. We compared the capability of amide proton transfer magnetic resonance imaging with that of noninvasive diffusion-weighted imaging and noninvasive 3-dimensional pseudo-continuous arterial spin imaging in evaluating the grading and cellularity of gliomas. Our results reveal that amide proton transfer magnetic resonance imaging is a superior imaging technique to diffusion-weighted imaging and 3-dimensional pseudo-continuous arterial spin imaging in the grading of gliomas. In addition, our results showed that the Ki-67 index correlated better with the amide proton transfer-weighted signal intensity than with the apparent diffusion coefficient value or the cerebral blood flow value in the gliomas. Amide proton transfer magnetic resonance imaging is a promising method for predicting the grading and cellularity of gliomas. |
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