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自动化研究所人才库

  • 姓名: 韩华
  • 性别: 男
  • 职称: 正高级
  • 电子邮件: hua.han@ia.ac.cn
    简  历:
  • 姓名

    韩华

    性别

    联系方式

     hua.han@ia.ac.cn

    专业技术职务

    研究员

    部门/实验室

    类脑智能研究中心

    通讯地址

    北京市海淀区中关村东路95号

    邮编

    100190

    研究领域

    随着脑科学和信息科学的发展,脑科学研究产生的数据量呈现爆发式增长,如脑图谱绘制、单细胞分型、光/电/磁记录等方面的数据规模已经进入大数据范畴。海量数据的产生带来新的问题,如何挖掘数据、展示数据、共享数据已成为神经科学研究领域新的重大挑战。

    微观重建团队聚焦于微观尺度脑连接图谱新技术研究,致力于海量电镜图像的高通量采集、实时处理、三维重建和智能分析等,基于脑连接图谱大数据对真实神经网络机制进行建模和阐释,为国家脑科学和类脑智能研究提供突触水平神经重建所需的技术服务、解决方案和共享平台。

    微观重建团队是目前国内唯一能够提供脑微观图谱全流程分析技术的成建制团队,合作成果发表于Science、Nature Communications、Nano Research、IJCAI、ISBI等。毕业生去向包括中科院自动化所、海南大学、华为、美团、阿里、IBM等。

    教育背景

    2001-09--2004-08   中国科学院研究生院   博士
    1996-09--1999-04   中国舰船研究院   硕士
    1992-09--1996-07   西安交通大学   学士

    工作简历

     

    2016-09~现在, 中国科学院大学, 岗位教授
    2015-07~现在, 中国科学院脑科学与智能技术卓越创新中心, 年轻骨干
    2014-10~现在, 中国科学院自动化所, 研究员
    2007-06~2014-10,中国科学院自动化所, 高级工程师
    2004-08~2007-06,中国科学院自动化所, 助理研究员
    1999-04~2001-08,江苏自动化研究所, 工程师

    发表论文

    (1) A common hub for sleep and motor control in the substantia nigra, Science, 2020, 其他(合作组作者)
    (2) Dual Networks for High-Precision and High-Speed Registration of Brain Electron Microscopy Images, Brain Sciences, 2020, 通讯作者
    (3) An Innovative Method for Screening and Evaluating the Degree of Diabetic Retinopathy and Drug Treatment Based on Artificial Intelligence Algorithms, Pharmacological Research, 2020, 通讯作者
    (4) Automatic reconstruction of mitochondria and endoplasmic reticulum in electron microscopy volumes by deep learning, Frontiers in Neuroscience, 2020, 通讯作者
    (5) SiamBOMB: A Real-time AI-based System for Home-cage Animal Tracking, Segmentation and Behavioral Analysis, IJCAI-PRICAI 2020, 2020, 通讯作者
    (6) Quality metrology of carbon nanotube thin films and its application for carbon nanotube-based electronics, Nano Research, 2020, 其他(合作组作者)
    (7) An Effective Encoder-Decoder Network for Neural Cell Bodies and Cell Nucleus Segmentation of EM Images, IEEE Engineering in Medicine and Biology Society(EMBC), 2019, 通讯作者
    (8) Automatic Classification for the Type of Multiple Synapse Based on Deep Learning, IEEE Engineering in Medicine and Biology Society(EMBC), 2019, 通讯作者
    (9) Electron Microscopic Sequential Images Stitching Based on Belief Propagation, International Conference on Graphic and Image Processing(ICGIP), 2019, 通讯作者
    (10) Using Scale Information to Improve SIFT-Based Electron Microscope Image Registration Method, International Conference on Graphic and Image Processing(ICGIP), 2019, 通讯作者
    (11) Brain Activity Regulates Loose Coupling between Mitochondrial and Cytosolic Ca Transients, Nature Communications, 2019, 其他(合作组作者)
    (12) Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution, National Science Review, 2019, 其他(合作组作者)
    (13) Skeleton-based Image Registration of Serial Electron Microscopy Sections, SPIE Medical Imaging. International Society for Optics and Photonics, 2019, 通讯作者
    (14) Deep Contextual Residual Network for Electron Microscopy Image Segmentation in Connectomics, 2018 IEEE International Symposium on Biomedical Imaging(ISBI), 2018, 通讯作者
    (15) A Novel 3D Connection Algorithm of Mitochondria from ATUM-SEM Stacks Based on Segmentation Information in Context, IEEE Engineering in Medicine and Biology Society(EMBC), 2018, 通讯作者
    (16) Automatic Detection and Segmentation of Mitochondria from SEM Images using Deep Neural Network, IEEE Engineering in Medicine and Biology Society(EMBC), 2018, 通讯作者
    (17) Large-area and highly uniform carbon nanotube film forhigh-performance thin film transistors, Nano Research, 2018, 其他(合作组作者)
    (18) Non-iterative simultaneous rigid registration method for serial sections of biological tissue, 2018 IEEE International Symposium on Biomedical Imaging(ISBI), 2018, 第 5 作者
    (19) 基于深度学习的脑微观结构重建, Brain Microstructure Reconstruction Based on Deep Learning, 系统工程理论与实践, 2018, 通讯作者
    (20) Real-time Image Deformation Using Locally-weighted Moving Least Squares, International Conference on Brain-Inspired Cognitive System?(BICS), 2018, 第 5 作者
    (21) Fully Automatic Synaptic Cleft Detection and Segmentation From EM Images based on Deep Learning, International Conference on Brain-Inspired Cognitive System?(BICS), 2018, 通讯作者
    (22) A Fast Forward 3D Connection Algorithm for Mitochondria and Synapse Segmentations from Serial EM Images, BioData Mining, 2018, 通讯作者
    (23) A Refined Spatial Transformer Network, International Conference on Neural Information Processing, 2018, 通讯作者
    (24) Correlative light and electron microscopy for complex cellular structures on PDMS substrates with coded micro-patterns, Lab on a Chip, 2018, 其他(合作组作者)
    (25) Automatic mitochondria segmentation for EM data using a 3D supervised convolutional network, Frontiers in Neuroanatomy, 2018, 通讯作者
    (26) Morphology-Retained Non-Linear Image Registration of Serial Electron Microscopy Sections, IEEE International Conference on Image Processing (ICIP), 2018, 通讯作者
    (27) Image deformation based on contour using moving integral least squares, IET Image Processing, 2018, 第 6 作者
    (28) An Unsupervised Network for Fast Microscopic Image Registration, SPIE Medical Imaging, 2018, 第 4 作者
    (29) A Effective Fully Deep Convolutional Neural Networks for Mitochondria Segmentation Based on ATUM-SEM, SPIE Medical Imaging, 2018, 通讯作者
    (30) Effective Automated Pipeline for 3D Reconstruction of Synapses Based on Deep Learning, BMC Bioinformatics, 2018, 通讯作者
    (31) Formation mechanism of anodic titanium oxide in mixed electrolytes, Materials Research Bulletin, 2017, 通讯作者
    (32) An efficient method for neuronal tracking in electron microscopy images, The 2017 IEEE International Conference on Mechatronics and Automation(ICMA), 2017, 第 6 作者
    (33) Large scale three-dimensional reconstruction of an entire Caenorhabditis elegans larva using AutoCUTS-SEM, Journal of Structural Biology, 2017, 其他(合作组作者)
    (34) 3D reconstruction of synapses with deep learning based on EM Images, SPIE Medical Imaging, 2017, 通讯作者
    (35) An automated detection for axonal boutons in vivo two-photon imaging of mouse, Eighth International Conference on Graphic and Image Processing., 2017, 第 5 作者
    (36) Learning with Coefficient-based Regularized Regression on Markov Resampling, IEEE Transactions on Neural Networks and Learning Systems, 2017, 其他(合作组作者)
    (37) An Automated Pipeline for Bouton, Spine, and Synapse Detection of In vivo Two-photon Images of Mouse, Biodata Mining, 2017, 通讯作者
    (38) 脑微观重建系统研究, Micro reconstruction system for brain, 系统工程理论与实践, 2017, 通讯作者
    (39) GAN based Sample Simulation for SEM-Image Super Resolution, CCF Chinese Conference on Computer Vision, 2017, 第 5 作者
    (40) Image Deformation Using modified Moving Least Squares with outlines, The 2017 IEEE International Conference on Mechatronics and Automation(ICMA), 2017, 第 6 作者
    (41) Grayscale Inhomogeneity Correction Method for Multiple Mosaicked Electron Microscope Images, International Conference on Graphic and Image Processing(ICGIP), 2017, 第 4 作者
    (42) Automatical Detecting and Connecting the Mitochondria From the Serial EM Images, The 2017 IEEE International Conference on Mechatronics and Automation(ICMA), 2017, 第 6 作者
    (43) Microscopic Neural Image Registration based on the Structure of Mitochondria, SPIE Medical Imaging, 2017, 第 2 作者
    (44) Deep Learning and Shapes Similarity for Joint Segmentation and Tracing single Neurons in SEM images, SPIE Medical Imaging, 2017, 通讯作者
    (45) An Automated Pipeline for Mitochondrial Segmentation on ATUM-SEM Stacks, Journal of Bioinformatics and Computational Biology, 2017, 通讯作者
    (46) Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity, Cell Research, 2017, 其他(合作组作者)
    (47) Watershed learning merge tree used for segmenting neurons in SEM images, The 2017 IEEE International Conference on Mechatronics and Automation(ICMA), 2017, 通讯作者
    (48) Automatically Segmenting and Reconstructing Neurons in SEM images, The 2016 IEEE International Conference on Mechatronics and Automation(ICMA), 2016, 通讯作者
    (49) Sequentially Supervised Long Short-Term Memory for Gesture Recognition, Journal Cognitive Computation, 2016, 其他(合作组作者)
    (50) Wrinkle Image Registration for Serial Microscopy Sections, International Conference on Signal-Image Technology & Internet-Based Systems, 2015, 通讯作者
    (51) Simulation of anodizing current-time curves and morphology evolution of TiO 2 nanotube arrays, J Solid State Electrochem, 2014, 通讯作者
    (52) 还原剂对多孔阳极氧化铝纳米孔道结构的影响, Influence of Reducer on the Nanopore Structure of Porous Anodic Alumina, 物理化学学报, 2012, 通讯作者
    (53) Correction of SEM Image Distortion based on Non-equidistant GM(1,1) Model, Proceedings of the 2012 International Conference on Wavelet Analysis and Pattern Recognition, Xian, China, 2012, 第 2 作者
    (54) A Fast Acquisition System for Large-scale Optical Microscopic Integrated Circuit Chip Images Based on Thin Plate Spline, Proceedings of the 2012 International Conference on Sensors, Measurement and Intelligent Materials, Guilin, China, 2012, 通讯作者
    (55) 多孔阳极氧化物的形成效率与纳米孔道的形成机理, Forming efficiency of porous anodic oxide and formation mechanism of nanopores, 物理学报, 2012, 通讯作者
    (56) β展式的误差和函数, The Error-Sum Function of Beta Expansion , 数学的实践与认识, 2011, 通讯作者
    (57) Image super-resolution based on image adaptive decomposition, Proc. of SPIE MIPPR 2011: Parallel Processing of Images and Optimization and Medical Imaging Processing, 2011, 通讯作者
    (58)  An efficient algorithm and FPGA implementation of video luminance transient improvement, High Technology Letters, 2010, 第 3 作者
    (59) Video Luminance Transient Improvement Using Difference-of-Gaussian, Proceedings of the 15th Asia-Pacific Conference on Communications, 2009, 第 3 作者
    (60) 经验模式分解算法的分析及其应用, 系统工程理论与实践, 2009, 通讯作者
    (61)  A spatial deinterlacing algorithm based on edge orientation optimized in local area, CISP 08 Proceedings of the 2008 Congress on Image and Signal Processing, 2008, 第 2 作者

    专利成果

    ( 1 ) 一种基于MCA的图像超分辨率重建方法, 发明, 2015, 第 1 作者, 专利号: ZL 201110014847.1
    ( 2 ) 一种基于图像边缘保持自适应分解的超分辨率重建方法, 发明, 2014, 第 2 作者, 专利号: ZL 201110014854.1
    ( 3 ) 基于带限二维EVD与Gabor自适应滤波的图像时频分析法, 发明, 2014, 第 2 作者, 专利号: ZL 201110014849.0
    ( 4 ) 利用自适应多尺度基本形式实现图像融合的方法, 发明, 2014, 第 3 作者, 专利号: ZL 201110014854.2
    ( 5 ) 一种基于多尺度基本形式的相似尺度图像融合方法, 发明, 2014, 第 1 作者, 专利号: ZL 201110014846.7
    ( 6 ) 小波邻域高斯模型图像复原方法, 发明, 2014, 第 2 作者, 专利号: ZL 201110014853.7
    ( 7 ) 一种对扫描电子显微镜畸变进行校正的方法, 发明, 2015, 第 2 作者, 专利号: ZL 201110014855.6
    ( 8 ) 显著化生物组织切片膜结构的刻蚀工艺及图像合成方法, 发明, 2018, 第 1 作者, 专利号: ZL 201510450536.8
    ( 9 ) 基于双光子图像的突触检测方法, 发明, 2019, 第 2 作者, 专利号: ZL 201610716189.3
    ( 10 ) 基于电镜序列切片图像的突触检测方法, 发明, 2017, 第 2 作者, 专利号: 201610802612.1
    ( 11 ) 基于序列切片的显微镜图像采集方法, 发明, 2019, 第 3 作者, 专利号: ZL 201610978135.4
    ( 12 ) 基于线粒体结构的图像配准方法及装置、存储介质及设备, 发明, 2017, 第 2 作者, 专利号: 201710610438.5
    ( 13 ) 生物组织序列切片显微图像的配准方法及装置, 发明, 2017, 第 2 作者, 专利号: ZL 201710638426.3
    ( 14 ) 低能量背散射电子探测器, 发明, 2017, 第 2 作者, 专利号: ZL 201710936186.5
    ( 15 ) 面向序列切片的扫描电镜图像实时配准装置及方法, 发明, 2017, 第 2 作者, 专利号: ZL 201711248908.4
    ( 16 ) 多幅显微图像拼接中的灰度矫正方法及装置, 发明, 2017, 第 3 作者, 专利号: ZL 201711287182.5
    ( 17 ) 超薄切片机及其刀台, 发明, 2018, 第 4 作者, 专利号: ZL 201821474544.1
    ( 18 ) 大视场光学显微图像成像装置及方法, 发明, 2018, 第 2 作者, 专利号: ZL 201811213274.3
    ( 19 ) 显微序列图像拼接方法及装置, 发明, 2018, 第 2 作者, 专利号: ZL 201811213303.6
    ( 20 ) 生物样品三维结构的构建方法及装置, 发明, 2018, 第 3 作者, 专利号: ZL 201811213305.5
    ( 21 ) 基于序列切片的显微镜图像采集方法, 发明, 2020, 第 3 作者, 专利号: PCT/CN2016/104852
    ( 22 ) 用于镀膜仪制备连续导电薄膜的装置, 发明, 2020, 第 3 作者, 专利号: ZL 201910956375.8

    荣誉及奖励

    (1) 中国科学院关键技术人才, 院级, 2015

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